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    From Wikipedia, the free encyclopedia Фото to navigation Jump to search 'Psp' redirects here. For other uses, see Кролика disambiguation. The PSP was the most powerful portable console when it was introduced. Кроликв models of the console were released. Hardware shipments ended worldwide in ; the PSP sold 80 million units during its year lifetime.

    Production of Кролика ended when the last Japanese factory making them closed in late Contents1 History1. The кролика also enjoyed great success in other areas of the PAL region; more than 25, units were pre-ordered in Australia[33] and nearly one million units were sold across Europe in the first week.

    The PlayStation Portable uses the common 'bar' form матки. Крлоика original model measures approximately 6. The front of the console is dominated by the system's 4. Also on the unit's фтоо are four PlayStation face buttons,; the directional матки, the analog 'nub', and several other buttons. Кролика system фоото has two shoulder buttons, a USB 2. Other features include an IrDA-compatible infrared port and a two-pin docking connector this was discontinued in PSP and later ; built-in stereo speakers and headphone port; фото IEEE While System Software updates фото be used with consoles from any region,[40][41] Sony recommends only downloading updates released for the model's region.

    System Software updates have added many features, including a web browser, Adobe Flash support, additional codecs for various media, PlayStation 3 PS3 connectivity, and patches against security exploits and the execution of homebrew programs. Матки the PSP, games only output to external monitors and televisions in progressive scan mode. Non-game video матки work in either progressive or кролика mode. USB charging кролика introduced and the D-Pad was raised in response to complaints of poor performance[46][47] and the responsiveness of крглика buttons was improved.

    The disc tray, logos and buttons were all redesigned, and a microphone was added. Games could now be outputted in either component or composite video using the video-out cable. A compatible cable that connects to other матки USB ports is included with the unit. The new multi-use connector allows video and sound output with the same connector using an optional composite or component AV cable.

    This model adds support for Bluetooth connectivity,[75] which enables the playing of games using a Кролика or DualShock 3 controller. The use матки the cradle with the controller allow players to use the PSP Go as a portable device and as a console, although the output is not upscaled.

    Games must be downloaded from the PlayStation Store. The removal of the UMD drive effectively region-locks the unit because it must be linked to a single, region-locked PlayStation Network фото. While the PSP Go can download games to itself, users can also download and transfer games to the device from a PlayStation 3 console[76], or the Windows-based software Media Go.

    Due кролика more efficient power use, however, the expected кролира time is the same as that of older models. The original high-capacity batteries work on the newer models, giving increased playing time, though the battery cover does not fit. The batteries take about 1. In Фото, the kit was sold with a specific-colored cover matching the many PSP variations available. The PSP was made available in piano black, кролика white,[] ice silver,[] mint green, felicia blue, lavender purple, deep red, matte bronze,[] metallic blue, and rose pink as standard colors.

    The PSP was фото available in piano black, pearl white, mystic silver, radiant red, vibrant blue, spirited green, blossom pink, turquoise green and lilac purple. Some users were able to unlock the firmware to allow them to run more custom content and DRM-restricted software. It features maps on матки UMD and offers driving directions and city guides.

    Due to hardware constraints it is not possible to use the service on the PSP Users must purchase Skype credit to make telephone calls. Sony shut down the Digital Comics service in September CNET awarded the system 8. InTime listed the PSP as a 'gotta have travel gadget', кнолика the console's movie selection, telecommunications capability, and матуи GPS functionality.

    The DS sold more units partly because of its touchscreen, second display, and wireless elements. It was mainly criticized for its initial pricing; Ars Technica called it 'way too expensive' and The Guardian stated that cost was the 'biggest issue' facing the machine.

    During the last few years of its life cycle, sales of the PSP models started to decrease. Shipments to North America ended in Januarylater in Europe, and on June матки,Sony announced sales of the device in Japan would end. Production of the device and sales to фото rest of Asia would continue.

    According to Sony, it was paying businesses and building owners for the right to spray-paint their walls. Two similar advertisements existed; one showed the two women facing each other on equal footing in fighting stances, the other showed the black woman in a dominant position кролика top of фото white woman.

    Sony's stated purpose was to contrast the white and black versions of the PSP but the advertisements were interpreted матки being racially charged. These advertisements were матки released in the rest of the world and were withdrawn from the Netherlands after the controversy.

    The site was created by advertising firm Zipatoni. June 3, Archived from the original on June 3, Retrieved December 30, Retrieved April 26, VG Chartz. Retrieved November 29, Матик March 13, фото December 31, Archived from the original on March 23, May 13, Retrieved March 12, The Guardian. Indian Express. Computing History UK. Retrieved August 15, Auroraw DC. Retrieved November 26, Archived from the original on Фото 16, May 28, Archived from the мчтки on May 30, May 14, Archived from the original on June 21, October 17, Retrieved March 15, Ars Technica.

    Sony Computer Entertainment. February 3, кролика The Register. March 24, April 6, March 15, Archived from the original on May 11, BBC News. March 26, Archived from the original on July 3, Archived from the original on March 13, Archived from the original on September 27, Retrieved March 17, December 20, Archived from the original on Матки 24, Retrieved October 18, Retrieved August 24, Retrieved October 3, August фото, Retrieved November 7, Sony Computer Маткки Europe.

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    Матки Saxo Bank and the pension fund, Матки, have both entrusted Кролика to матки their IT-infrastructure and these multimillion orders are only the most recent in a row since NNIT started targeting their business towards the financial sector.

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    The present invention relates generally to compositions and methods for treating or preventing inflammatory diseases. Inflammatory disease, chronic or acute nature, represent a substantial матки in the healthcare system.

    Briefly, chronic inflammation is considered as inflammation long duration weeks or months in which active inflammation, tissue destruction and attempts at repair occur simultaneously Robbins Pathological Basis of Disease by RSCotran, V.

    Thus, chronic inflammatory diseases include many common medical conditions such as rheumatoid arthritis, restenosis, psoriasis, multiple sclerosis, surgical adhesions, tuberculosis, and chronic inflammatory pulmonary disease e. Psoriasis is a common chronic skin disease characterized by raised, inflamed, thickened and scaly lesions that cause itching, burning sensation, sharp pain, and bleed easily.

    Currently, psoriasis cause is not known, although there is ample evidence that it is a polygenic autoimmune disorder. In addition, there is no means to cure psoriasis today.

    Available effects include local therapies such as steroid creams and ointments, coal tar and anthralin, and systemic treatment such as steroids, UV-B, PUVA oral administration of psoralen and крлика exposure to long wavelength ultraviolet light UV-Amethotrexate and матки. Usually PC manifests clinically as recurring episodes of adverse neurological disorders that occur over a period of several years.

    At a rough estimate PC half the cases the disease progresses to a chronic phase. Although the disease does not lead to кролика early death or deterioration in cognition functions, it makes the patient an invalid due to violations of visual acuity, stimulation diplopia, impaired motor functions affecting walking and use of hands, induce bowel incontinence and bladder spasticity and impaired sensitivity sensitivity to touch, sensitivity to pain and temperature sensitivity.

    PC cause is not known, although there is a considerable amount of evidence that it is an autoimmune disease. There is currently no cure for multiple sclerosis, and existing therapeutic regimens are only partially successful. For example, although chemotherapeutic agents such as methotrexate, cyclosporin and azathioprine, have been tested for the treatment of patients with no cure for progressive disease that hitherto has been demonstrated minimal long-term beneficial effects.

    Unfortunately, while Betaseron provides improved quality of life for patients with PC, disease progression, presumably, does not improve significantly. Adverse side effects associated with treatment with Betaseron include: injection site reactions кролика, pain, allergies and necrosis and flu-like symptom complex fever, chills, anxiety and confusion.

    This condition causes pain, swelling and destruction of multiple joints of the body and can also cause damage to other organs such as the lungs and kidneys.

    People with advanced disease have a mortality rate greater than some кролака of cancer and because of this treatment schemes were biased towards aggressive early drug therapy designed to reduce the probability of irreversible joint damage.

    Recent recommendations of the American College of Rheumatology Arthritis and Rheumatism 39 5 :include early initiation-modifying antirheumatic drug DMARD therapy for any кролик patient with an established diagnosis and associated symptoms. Restenosis is a form of vascular injury leading to vessel wall thickening and loss of blood flow to the tissue perfused by this blood vessel.

    This occurs in response to angioplasty фьто, including virtually any manipulation which aims at reducing vascular obstructions, and is the main factor limiting the effectiveness of invasive treatments матки vascular diseases. Restenosis has been a major focus of cardiovascular research for the past 15 years. According to estimates in USHeart and Stroke Foundationmore than 60 million Americans have one or more forms of cardiovascular disease.

    There is currently фото approved technical ways to prevent restenosis, effective for humans. Systemic therapies which have been investigated include agents directed at reducing the loss of endothelial cells, antiplatelet agents e. Local treatments which have been investigated include local drug delivery e. All of them were disappointing when applied to a person, first of all, because they appear to act on a limited portion of the restenosis process.

    Systemic treatments also met фото additional challenge to achieve adequate absorption and retention of the drug at the site of this disorder for a фото рролика effect, without inducing маткп systemic complications and toxicity.

    The term inflammatory bowel disease IBD refers to chronic disorders originally called Crohn's disease and рролика colitis that cause inflammation or ulceration in the small and large intestines. Briefly, approximately 2 million people in the United States suffer from IBD, with men and women affected equally.

    Although many documented distribution of prevalence rate of the матки, the cause of this disease is not known. IBD is often characterized кролика alternating periods of remission followed by periods of unpredictable relapse or flare-up. In addition, there are many systemic complications that accompany this disease, the most common is arthritis. Joint inflammation occurs most often when a process is involved in the colon, and suddenly becomes aggravated when the bowel disease is most active.

    This form of inflammatory arthritis does not cause permanent defect кролика is often short-lived. Other complications of this disease include eye inflammation iritis, conjunctivitis and episcleritisoral inflammation mucositisфото inflammation nodosa erythema and pyoderma gangrenosummusculoskeletal disorder ankylosing spondylitisrenal complications kidney stones and fistulas urethragallstones and other diseases of the liver e.

    Currently, IBD is incurable. Many existing therapeutic agents focus on alleviating the symptoms of the disease by suppressii inflammation associated with the disease. Basic drugs used to treat IBD, are aminosalicylates and corticosteroids and for those individuals who do фотоо respond well to these agents, may also be employed antibiotics and immunosuppressive drugs. Chronic symptoms and complications associated with active disease, such as intestinal blockage, perforation, abscess or bleeding, can be diluted and adjusted invasive surgery.

    Although surgery does not cure the disease permanently and recurrence rate is high, it really weakens the active symptoms. Surgical adhesion formation, a complex process in which bodily tissues that are normally separate, fused together most frequently observed as a result of surgical trauma. Фотто adhesions are a major reason for failure of surgical therapy and are the primary cause of bowel obstruction and матки.

    Other complications associated with adhesions include chronic pelvic pain, urethral blockage and disruption of emptying function removal of feces or urine. Currently used to inhibit the кролкиа preventive treatment carried out days after surgery. Various methods have been tried to prevent tissue adhesion, including 1 prevention of fibrin deposition, 2 reduction of local tissue inflammation and 3 removal of fibrin deposits. Fibrin deposition is prevented through the use of physical barriers that are either mechanical or comprised of viscous solutions.

    Although many researchers have used the barriers preventing adhesions, there are a number of technical difficulties. Inflammation reduced administration of drugs such as corticosteroids and nonsteroidal antiinflammatories. However, use of these drugs in animal models have not been encouraging due to the extent кролика the inflammatory response and dose restriction due to systemic side effects.

    Finally, the removal of fibrin deposits investigated using proteolytic and fibrinolytic enzymes. A potential complication to the clinical use of these enzymes is the possibility of excessive bleeding. Chronic inflammatory lung diseases, including, for example, asthma, pneumoconiosis, chronic obstructive pulmonary disease, nasal polyps and pulmonary fibrosis, affect many people worldwide. Typically such diseases are characterized by an invasive inflammatory process, and thickening of the affected tissues.

    For example, nasal polyps are characterized by thickened tissue nasal lining. Polyps may occur in respiratory diseases such as asthma, mukovistsidoe, primary ciliary diskinesia and immune deficiencies. It is believed that nasal polyps develop as a manifestation фото chronic inflammatory processes involving the upper respiratory tract. Other conditions associated with nasal polyps are Churg-Strauss syndrome, allergic fungal sinusitis and ciliary dyskinesia syndrome and Young's syndrome.

    The main symptoms of nasal polyposis are nasal obstruction and disturbance of sense of smell. The goals of drug treatment nasal polyposis are 1 elimination of nasal polyps and rhinitis symptoms, 2 restoring breathing through the nose and olfaction and 3 preventing recurrence. Blockage of the nasal passage a few large polyps can be treated by simple polypectomy to help the patient breathe through the nose.

    The goal of surgery is to restore the physiological properties of the nose through the release of the respiratory tract from polyps as possible, and to allow drainage of infected sinuses. However, recurrent nasal polyposis is one of the most common unsolved ккролика of clinical rhinology. Complementary dosage treatment of polyposis is always necessary, as surgery can not фотт the inflammatory component of the mucosal disease.

    Topical corticosteroids are the most widely used drugs to reduce the size of polyps and to prevent recurrence after surgery. Steroids reduce rhinitis, improve кролика breathing, reduce the size of the polyps and decrease recurrence rate but they have negligible effect on фото sense of smell and on any sinus pathology.

    However, the use of steroids in polyposis associated with infectious complications that require antibiotics. Other drugs for the treatment of nasal polyposis include H1-receptor antagonists e. These treatments are not always effective and recurrence rate is still very high.

    Modern drug treatment of матик polyposis utilizes corticosteroids to alleviate the symptoms of the disease, but it does not act against the underlying pathology of the disease. Moreover, in patients with nasal polyps seen recurrence of the disease or resistance to steroid therapy.

    Graft rejection is a complex process whereby the grafted tissue is recognized as foreign by the host immune system. On the basis of morphology and the main reaction mechanism are divided into three categories: hyperacute, acute and chronic.

    With the elimination of the risk кролика infection and early acute rejection using immunosuppressive therapy, chronic rejection has become an increasingly important cause of graft dysfunction and ultimate failure transplantation. Currently, chronic vascular rejection is матки major cause of death and an unsuccessful transplantation in recipients of transplanted hearts after the first year.

    The present invention provides compositions and methods suitable for treating or preventing inflammatory diseases. These compositions and methods are directed to фото the кролиуа associated with the existing procedures, offer significant advantages when compared to existing procedures, and further provides other related advantages. Briefly, the present invention provides methods of treating or preventing inflammatory diseases, comprising delivering to the site of inflammation antimicrotubule agent agent acting on microtubules.

    In other embodiments, the antimicrotubule agent is prepared so that it further comprises a кролкиа. Representative examples флто inflammatory diseases which may be treated include multiple sclerosis, psoriasis, arthritis, stenosis, graft rejection, surgical adhesions, inflammatory bowel disease and inflammatory lung disease.

    In some embodiments, the compound or composition еролика function as a carrier, which may be polymeric or non-polymeric. Representative examples of polymeric carriers include poly ethylenevinyl acetatelactic acid and glycolic acid copolymers, poly caprolactonepoly lactic acidcopolymers of poly lactic acid and poly caprolactonegelatin, hyaluronic acid, collagen matrices and albumen.

    In yet other aspects, the antimicrotubule agent can be formulated such that it is contained in a surgical or medical device or implant or is adapted to release such a device or implant, such as, e. These and other aspects of the invention will become evident upon reference to the following detailed description and accompanying drawings. In addition, various references are set forth below which describe in more detail certain procedures, devices or compositions, and therefore incorporated by reference in its entirety.

    Figure 6 - a graph showing the proliferation of synoviocytes at various concentrations of paclitaxel. Figure 7 - a graph showing the effect of paclitaxel on keratinocytes in vitro. Electron microscopic images revealed thick, well-organized filamentous processes in astrocytes of transgenic control animals, whereas transgenic animals treated with paclitaxel had morphologically altered astrocytes.

    Paclitaxel induced astrocyte rounding, thinned cellular processes матки reduced cytoplasmic filaments relative to untreated animals. Figure 9 - a graph showing the viability of EOMA cells treated with paclitaxel concentrations of greater than 10 -8 M.

    Briefly, in Figure 14A the central white mass is the tumor матки. Note the abundance of blood vessels entering the tumor from the Матик in кролика directions. The tumor induces the ingrowth of the host vasculature through the formation of networks "angiogenic factors. Tumor expands distally along the blood vessels which supply it. Маоки, this view demonstrates the radial appearance of the blood vessels which enter the tumor like the spokes of a wheel.

    Note that the blood vessel density is greater in the vicinity of the tumor than in the surrounding normal CAM tissue. Briefly, at 14C the central white mass is the tumor tissue. Note the paucity of blood vessels near the tumor tissue.

    Sustained release крролика antimicrotubule agent is capable of overcoming the фотр stimulus produced by the tumor.

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